Acute toxicity Totally Explained

Everything about Acute Toxicity totally explained

Acute toxicity describes the adverse effects of a substance which result either from a single exposure or from multiple exposures in a short space of time (usually less than 24 hours). To be described as acute toxicity, the adverse effects should occur within 14 days of the administration of the substance.

Measures of acute toxicity

Regulatory values

Limits for short-term exposure, such as STELs or CVs, are only defined if there a particular acute toxicity associated with a substance.

Short-term exposure limit, STEL; Threshold limit value-short-term exposure limit, TLV-STEL
Ceiling value, CV; Threshold limit value-ceiling, TLV-C

Experimental values

No observed adverse effect level, NOAEL

Lowest observed adverse effect level, LOAEL

Maximum tolerable concentration, MTC, LC₀; Maximum tolerable dose, MTD, LD₀

Minimum lethal concentration, LC_min; Mimimum lethal dose, LD_min

Median lethal concentration, LC₅₀; Median lethal dose, LD₅₀; Median lethal time, LT₅₀

Absolute lethal concentration, LC₁₀₀; Absolute lethal dose, LD₁₀₀Further Information

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